Reaction Details  Report a problem with these data
Target
Group 10 secretory phospholipase A2
Ligand
BDBM50366984
Substrate
n/a
Meas. Tech.
ChEMBL_1735577 (CHEMBL4151113)
IC50
4800±n/a nM
Citation
 Knerr, L; Giordanetto, F; Nordberg, P; Pettersen, D; Selmi, N; Beisel, HG; de la Motte, H; Olsson, T; Perkins, TDJ; Herslöf, M; Månsson, Å; Dahlström, M; Starke, I; Broddefalk, J; Saarinen, G; Klingegård, F; Hurt-Camejo, E; Rosengren, B; Brengdahl, J; Jansen, F; Rohman, M; Sandmark, J; Hallberg, K; Åkerud, T; Roth, RG; Ahlqvist, M Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A ACS Med Chem Lett 9:594-599 (2018) [PubMed]  Article
Target
Name:
Group 10 secretory phospholipase A2
Synonyms:
Group X secretory phospholipase A2 | PA2GX_HUMAN | PLA2G10
Type:
PROTEIN
Mol. Mass.:
18153.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1442449
Residue:
165
Sequence:
MGPLPVCLPIMLLLLLPSLLLLLLLPGPGSGEASRILRVHRRGILELAGTVGCVGPRTPIAYMKYGCFCGLGGHGQPRDAIDWCCHGHDCCYTRAEEAGCSPKTERYSWQCVNQSVLCGPAENKCQELLCKCDQEIANCLAQTEYNLKYLFYPQFLCEPDSPKCD
  
Inhibitor
Name:
BDBM50366984
Synonyms:
CHEMBL4172025
Type:
Small organic molecule
Emp. Form.:
C19H19N3O4S
Mol. Mass.:
385.437
SMILES:
CS(=O)(=O)NC(=O)CCc1cccc(c1)-n1c(cc2ccccc12)C(N)=O
Structure:
Search PDB for entries with ligand similarity: