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Target
Quinolone resistance protein NorA
Ligand
BDBM50449607
Substrate
n/a
Meas. Tech.
ChEMBL_1740218 (CHEMBL4155968)
IC50
5000±n/a nM
Citation
 Felicetti, T; Cannalire, R; Nizi, MG; Tabarrini, O; Massari, S; Barreca, ML; Manfroni, G; Schindler, BD; Cecchetti, V; Kaatz, GW; Sabatini, S Studies on 2-phenylquinoline Staphylococcus aureus NorA efflux pump inhibitors: New insights on the C-6 position. Eur J Med Chem 155:428-433 (2018) [PubMed]  Article
Target
Name:
Quinolone resistance protein NorA
Synonyms:
NORA_STAAU | norA
Type:
PROTEIN
Mol. Mass.:
42273.03
Organism:
Staphylococcus aureus
Description:
ChEMBL_961221
Residue:
388
Sequence:
MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDISIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVVIVLIEKQHRAKLKEQNM
  
Inhibitor
Name:
BDBM50449607
Synonyms:
CHEMBL4168471
Type:
Small organic molecule
Emp. Form.:
C31H43N3O4
Mol. Mass.:
521.6908
SMILES:
CCCOc1ccc(cc1)-c1cc(OCCN(CC)CC)c2cc(OCCCN3CCOCC3)ccc2n1
Structure:
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