Reaction Details  Report a problem with these data
Target
Free fatty acid receptor 2
Ligand
BDBM50450260
Substrate
n/a
Meas. Tech.
ChEMBL_1742408 (CHEMBL4158158)
EC50
912±n/a nM
Citation
 Hansen, AH; Sergeev, E; Bolognini, D; Sprenger, RR; Ekberg, JH; Ejsing, CS; McKenzie, CJ; Rexen Ulven, E; Milligan, G; Ulven, T Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties. J Med Chem 61:9534-9550 (2018) [PubMed]  Article
Target
Name:
Free fatty acid receptor 2
Synonyms:
FFA2 | FFAR2 | FFAR2_HUMAN | G-protein coupled receptor 43 | GPCR43 | GPR43
Type:
PROTEIN
Mol. Mass.:
37156.44
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1508993
Residue:
330
Sequence:
MLPDWKSSLILMAYIIIFLTGLPANLLALRAFVGRIRQPQPAPVHILLLSLTLADLLLLLLLPFKIIEAASNFRWYLPKVVCALTSFGFYSSIYCSTWLLAGISIERYLGVAFPVQYKLSRRPLYGVIAALVAWVMSFGHCTIVIIVQYLNTTEQVRSGNEITCYENFTDNQLDVVLPVRLELCLVLFFIPMAVTIFCYWRFVWIMLSQPLVGAQRRRRAVGLAVVTLLNFLVCFGPYNVSHLVGYHQRKSPWWRSIAVVFSSLNASLDPLLFYFSSSVVRRAFGRGLQVLRNQGSSLLGRRGKDTAEGTNEDRGVGQGEGMPSSDFTTE
  
Inhibitor
Name:
BDBM50450260
Synonyms:
CHEMBL4161397
Type:
Small organic molecule
Emp. Form.:
C23H17Cl2NO3S
Mol. Mass.:
458.357
SMILES:
OC(=O)[C@@H]1CS[C@@H](N1C(=O)c1ccc(cc1)-c1ccccc1Cl)c1ccccc1Cl |r|
Structure:
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