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Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha/beta
Ligand
BDBM292485
Substrate
n/a
Meas. Tech.
ChEMBL_1749667 (CHEMBL4184427)
EC50
120±n/a nM
Citation
  TBA Bioorg Med Chem Lett 28:541-546 (2018) [PubMed]  Article
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha/beta
Synonyms:
CaM kinase II alpha/beta
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1749667
Components:
This complex has 2 components.
Component 1
Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Synonyms:
CaM Kinase II | Calcium/calmodulin-dependent protein kinase type II, rat brain | Camk2a | KCC2A_RAT | calcium/calmodulin-dependent protein kinase II alpha subunit
Type:
Enzyme Mixture
Mol. Mass.:
54120.65
Organism:
Rattus norvegicus (rat)
Description:
Consists of subunits of M.W. 50,000 and 58,000-60,000 in a 3:1 ratio.
Residue:
478
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
  
Component 2
Name:
Calcium/calmodulin-dependent protein kinase type II subunit beta
Synonyms:
2.7.11.17 | CaM kinase II subunit beta | CaMK-II subunit beta | Calcium/calmodulin-dependent protein kinase type II subunit beta | Camk2b | KCC2B_RAT
Type:
PROTEIN
Mol. Mass.:
60408.67
Organism:
Rattus norvegicus
Description:
ChEMBL_118320
Residue:
542
Sequence:
MATTVTCTRFTDEYQLYEDIGKGAFSVVRRCVKLCTGHEYAAKIINTKKLSARDHQKLEREARICRLLKHSNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKEAYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITAHEALKHPWVCQRSTVASMMHRQETVECLKKFNARRKLKGAILTTMLATRNFSVGRQTTAPATMSTAASGTTMGLVEQAKSLLNKKADGVKPQTNSTKNSSAITSPKGSLPPAALEPQTTVIHNPVDGIKESSDSTNTTIEDEDAKARKQEIIKTTEQLIEAVNNGDFEAYAKICDPGLTSFEPEALGNLVEGMDFHRFYFENLLAKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRPDGKWQNVHFHCSGAPVAPLQ
  
Inhibitor
Name:
BDBM292485
Synonyms:
(S)-N-(2-(diethylamino)propyl)-2-(3-methoxyazetidin-1-yl)-6-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)isonicotinamide | US10100058, Example 141
Type:
Small organic molecule
Emp. Form.:
C27H33N7O2S
Mol. Mass.:
519.662
SMILES:
CCN(CC)[C@@H](C)CNC(=O)c1cc(nc(c1)-c1cnn2ccc(nc12)-c1cccs1)N1CC(C1)OC |r|
Structure:
Search PDB for entries with ligand similarity: