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Target
Glycylpeptide N-tetradecanoyltransferase
Ligand
BDBM50033418
Substrate
n/a
Meas. Tech.
ChEMBL_1750774 (CHEMBL4185534)
IC50
12±n/a nM
Citation
 Buuh, ZY; Lyu, Z; Wang, RE Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins. J Med Chem 61:3239-3252 (2018) [PubMed]  Article
Target
Name:
Glycylpeptide N-tetradecanoyltransferase
Synonyms:
N-myristoyltransferase (NMT1) | NMT_ASPFU | nmt1
Type:
Protein
Mol. Mass.:
56263.84
Organism:
Aspergillus fumigatus
Description:
Q9UVX3
Residue:
492
Sequence:
MSDSKDRKGKAPEGQSSEKKDGAVNITPQMAESLLENNPALRNETAGMDKDKAAEAMRKMNIAELLTGLSVSGKNQKDMASYKFWQTQPVPRFDETSTDTGGPIKIIDPEKVSKEPDALLEGFEWATLDLTNETELQELWDLLTYHYVEDDNAMFRFRYSQSFLHWALMSPGWKKEWHVGVRATKSRKLVASICGVPTEINVRNQKLKVVEINFLCIHKKLRSKRLTPVLIKEITRRCYLNGIYQAIYTAGVVLPTPVSSCRYYHRPLDWLKLYEVGFSPLPAGSTKARQITKNHLPSTTSTPGLRPMEPKDIDTVHDLLQRYLSRFALNQAFTREEVDHWLVHKPETVKEQVVWAYVVEDPETHKITDFFSFYNLESTVIQNPKHDNVRAAYLYYYATETAFTNNMKALKERLLMLMNDALILAKKAHFDVFNALTLHDNPLFLEQLKFGAGDGQLHFYLYNYRTAPVPGGVNEKNLPDEKRMGGVGIVML
  
Inhibitor
Name:
BDBM50033418
Synonyms:
CHEMBL3357685
Type:
Small organic molecule
Emp. Form.:
C24H30Cl2N6O2S
Mol. Mass.:
537.505
SMILES:
CC(C)Cc1nn(C)c(C)c1NS(=O)(=O)c1c(Cl)cc(cc1Cl)-c1ccnc(c1)N1CCNCC1
Structure:
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