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Target
Vasopressin V2 receptor
Ligand
BDBM50020675
Substrate
n/a
Meas. Tech.
ChEBML_211260
Ki
5.3±n/a nM
Citation
 Yim, NC; Moore, ML; Huffman, WF; Bryan, HG; Chang, HL; Kinter, LB; Edwards, R; Stassen, FL; Schmidt, D; Heckman, G Potent antagonists of vasopressin antidiuretic activity that lack the beta,beta-cyclopentamethylene-beta-mercaptopropionic acid substitution at position 1. J Med Chem 29:2425-6 (1987) [PubMed]
Target
Name:
Vasopressin V2 receptor
Synonyms:
AVPR2 | V2R_PIG
Type:
PROTEIN
Mol. Mass.:
40556.17
Organism:
Sus scrofa
Description:
ChEMBL_214870
Residue:
370
Sequence:
MLRATTSAVPRALSWPAAPGNGSEREPLDDRDPLLARVELALLSTVFVAVALSNGLVLGALVRRGRRGRWAPMHVFIGHLCLADLAVALFQVLPQLAWDATYRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGDGSGVLDCWASFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHTSLVPGPAERAGGHRGGRRAGSPREGARVSAAMAKTARMTLVIVAVYVLCWAPFFLVQLWSVWDPKAPREGPPFVLLMLLASLNSCTNPWIYASFSSSISSELRSLLCCPRRRTPPSLRPQEESCATASSFSARDTSS
  
Inhibitor
Name:
BDBM50020675
Synonyms:
1-[13-Benzyl-7-carbamoylmethyl-16-(4-ethoxy-benzyl)-20,20-diethyl-10-isopropyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaaza-cycloicosane-4-carbonyl]-pyrrolidine-2-carboxylic acid [1-(carbamoylmethyl-carbamoyl)-4-guanidino-butyl]-amide | CHEMBL404820
Type:
Small organic molecule
Emp. Form.:
C52H77N13O11S2
Mol. Mass.:
1124.378
SMILES:
CCOc1ccc(C[C@H]2NC(=O)CC(CC)(CC)SSC[C@@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC2=O)C(C)C)C(=O)N2CCC[C@H]2C(=O)N[C@H](CCCNC(N)=N)C(=O)NCC(N)=O)cc1
Structure:
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