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Target
Potassium voltage-gated channel subfamily A member 2
Ligand
BDBM50456973
Substrate
n/a
Meas. Tech.
ChEMBL_1758560 (CHEMBL4193568)
IC50
>30000±n/a nM
Citation
 Zidar, N; ?ula, A; Toma?i?, T; Rogers, M; Kirby, RW; Tytgat, J; Peigneur, S; Kikelj, D; Ila?, J; Ma?i?, LP Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem 139:232-241 (2017) [PubMed]  Article
Target
Name:
Potassium voltage-gated channel subfamily A member 2
Synonyms:
HBK5 | HUKIV | KCNA2 | KCNA2_HUMAN | NGK1 | Potassium voltage-gated channel subfamily A member 2 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.2
Type:
PROTEIN
Mol. Mass.:
56695.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_334898
Residue:
499
Sequence:
MTVATGDPADEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERESQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
  
Inhibitor
Name:
BDBM50456973
Synonyms:
Clathrodin
Type:
Small organic molecule
Emp. Form.:
C11H13N5O
Mol. Mass.:
231.2538
SMILES:
Nc1ncc(\C=C\CNC(=O)c2ccc[nH]2)[nH]1
Structure:
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