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Target
Potassium voltage-gated channel subfamily A member 6
Ligand
BDBM50456975
Substrate
n/a
Meas. Tech.
ChEMBL_1758567 (CHEMBL4193575)
IC50
9800±n/a nM
Citation
 Zidar, N; ?ula, A; Toma?i?, T; Rogers, M; Kirby, RW; Tytgat, J; Peigneur, S; Kikelj, D; Ila?, J; Ma?i?, LP Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem 139:232-241 (2017) [PubMed]  Article
Target
Name:
Potassium voltage-gated channel subfamily A member 6
Synonyms:
KCNA6_RAT | Kcna6 | Potassium voltage-gated channel subfamily A member 6 | RCK2 | Voltage-gated potassium channel subunit Kv1.6 | Voltage-gated potassium channel subunit Kv2
Type:
PROTEIN
Mol. Mass.:
58869.11
Organism:
Rattus norvegicus
Description:
ChEMBL_117511
Residue:
530
Sequence:
MRSEKSLTLAAPGEVRGPEGEQQDAGEFQEAEGGGGCCSSERLVINISGLRYETQLRTLSLFPDTLLGDPGRRVRFFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFMEEIRFYQLGDEALAAFREDEGCLPEGGEDEKPLPSQPFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPQFRADGRGGSNEGSGTRMSPASRGSHEEEDEDEDSYAFPGSIPSGGLGTGGTSSFSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKAAFFRNIMNIIDLVAIFPYFITLGTELVQRHEQQPVSGGSGQNRQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADDVDSLFPSIPDAFWWAVVTMTTVGYGDMYPMTVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEQEEQGQYTHVTCGQPTPDLKATDNGLGKPDFAEASRERRSSYLPTPHRAYAEKRMLTEV
  
Inhibitor
Name:
BDBM50456975
Synonyms:
CHEMBL4213446
Type:
Small organic molecule
Emp. Form.:
C12H14BrN5O
Mol. Mass.:
324.176
SMILES:
Cc1[nH]c(cc1Br)C(=O)NC\C=C\c1c[nH]c(N)n1
Structure:
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