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Target
Carbonic anhydrase 12
Ligand
BDBM50457326
Substrate
n/a
Meas. Tech.
ChEMBL_1759330 (CHEMBL4194338)
Ki
280±n/a nM
Citation
 Cadoni, R; Pala, N; Lomelino, C; Mahon, BP; McKenna, R; Dallocchio, R; Dessė, A; Carcelli, M; Rogolino, D; Sanna, V; Rassu, M; Iaccarino, C; Vullo, D; Supuran, CT; Sechi, M Exploring Heteroaryl-pyrazole Carboxylic Acids as Human Carbonic Anhydrase XII Inhibitors. ACS Med Chem Lett 8:941-946 (2017) [PubMed]  Article
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50457326
Synonyms:
CHEMBL4204007
Type:
Small organic molecule
Emp. Form.:
C15H15N3O2
Mol. Mass.:
269.2985
SMILES:
CC(C)n1cc(-c2cc([nH]n2)C(O)=O)c2ccccc12
Structure:
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