Reaction Details 
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Phospholipase A2 group V
Ligand
BDBM50458608
Substrate
n/a
Meas. Tech.
ChEMBL_1764264 (CHEMBL4199511)
IC50
180±n/a nM
Citation
Giordanetto, F; Knerr, L; Nordberg, P; Pettersen, D; Selmi, N; Beisel, HG; de la Motte, H; Månsson, Å; Dahlström, M; Broddefalk, J; Saarinen, G; Klingegård, F; Hurt-Camejo, E; Rosengren, B; Wikström, J; Wågberg, M; Brengdahl, J; Rohman, M; Sandmark, J; Åkerud, T; Roth, RG; Jansen, F; Ahlqvist, M Design of Selective sPLA ACS Med Chem Lett 9:600-605 (2018) [PubMed] ArticleMore Info.:
Target
Name:
Phospholipase A2 group V
Synonyms:
PA2G5_HUMAN | PLA2G5 | Phospholipase A2 group V | Secretory phospholipase A2, group V (sPLA2-V)
Type:
Protein
Mol. Mass.:
15682.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
138
Sequence:
MKGLLPLAWFLACSVPAVQGGLLDLKSMIEKVTGKNALTNYGFYGCYCGWGGRGTPKDGTDWCCWAHDHCYGRLEEKGCNIRTQSYKYRFAWGVVTCEPGPFCHVNLCACDRKLVYCLKRNLRSYNPQYQYFPNILCS
Inhibitor
Name:
BDBM50458608
Synonyms:
CHEMBL4205008
Type:
Small organic molecule
Emp. Form.:
C19H16F3N3O4
Mol. Mass.:
407.3432
SMILES:
CC(Cc1ccnc(c1)-n1c(cc2ccc(OC(F)(F)F)cc12)C(N)=O)C(O)=O
Structure:
