Reaction Details  Report a problem with these data
Target
Alternative oxidase, mitochondrial
Ligand
BDBM50459778
Substrate
n/a
Meas. Tech.
ChEMBL_1767058 (CHEMBL4202305)
IC50
2.0±n/a nM
Citation
 Meco-Navas, A; Ebiloma, GU; Martín-Domínguez, A; Martínez-Benayas, I; Cueto-Díaz, EJ; Alhejely, AS; Balogun, EO; Saito, M; Matsui, M; Arai, N; Shiba, T; Harada, S; de Koning, HP; Dardonville, C SAR of 4-Alkoxybenzoic Acid Inhibitors of the Trypanosome Alternative Oxidase. ACS Med Chem Lett 9:923-928 (2018) [PubMed]  Article
Target
Name:
Alternative oxidase, mitochondrial
Synonyms:
1.-.-.- | AOX | AOX_TRYBB | Alternative oxidase, mitochondrial
Type:
PROTEIN
Mol. Mass.:
37603.97
Organism:
Trypanosoma brucei brucei
Description:
ChEMBL_117839
Residue:
329
Sequence:
MFRNHASRITAAAAPWVLRTACRQKSDAKTPVWGHTQLNRLSFLETVPVVPLRVSDESSEDRPTWSLPDIENVAITHKKPNGLVDTLAYRSVRTCRWLFDTFSLYRFGSITESKVISRCLFLETVAGVPGMVGGMLRHLSSLRYMTRDKGWINTLLVEAENERMHLMTFIELRQPGLPLRVSIIITQAIMYLFLLVAYVISPRFVHRFVGYLEEEAVITYTGVMRAIDEGRLRPTKNDVPEVARVYWNLSKNATFRDLINVIRADEAEHRVVNHTFADMHEKRLQNSVNPFVVLKKNPEEMYSNQPSGKTRTDFGSEGAKTASNVNKHV
  
Inhibitor
Name:
BDBM50459778
Synonyms:
Ascofuranone | US11565996, Compound Ascochlorin
Type:
Small organic molecule
Emp. Form.:
C23H29ClO5
Mol. Mass.:
420.926
SMILES:
[H][C@]1(CC(=O)C(C)(C)O1)C(\C)=C\CC\C(C)=C\Cc1c(O)c(Cl)c(C)c(C=O)c1O |r|
Structure:
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