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Target
Histamine H3 receptor
Ligand
BDBM50459836
Substrate
n/a
Meas. Tech.
ChEMBL_1767246 (CHEMBL4219358)
Ki
8.8±n/a nM
Citation
 Kuder, KJ; ?a?ewska, D; Kaleta, M; Latacz, G; Kottke, T; Olejarz, A; Karcz, T; Fruzi?ski, A; Szczepa?ska, K; Karolak-Wojciechowska, J; Stark, H; Kie?-Kononowicz, K Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H Bioorg Med Chem 25:2701-2712 (2017) [PubMed]  Article
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50459836
Synonyms:
CHEMBL4227989
Type:
Small organic molecule
Emp. Form.:
C23H37NO5
Mol. Mass.:
407.5436
SMILES:
OC(=O)C(O)=O.CCC(C)(C)c1ccc(OCCCCCN2CCCCC2)cc1
Structure:
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