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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50460726
Substrate
n/a
Meas. Tech.
ChEMBL_1770185 (CHEMBL4222297)
IC50
>40000±n/a nM
Citation
 Patouret, R; Doebelin, C; Garcia-Ordonez, RD; Chang, MR; Ruiz, C; Cameron, MD; Griffin, PR; Kamenecka, TM Identification of an aminothiazole series of ROR? modulators. Bioorg Med Chem Lett 28:1178-1181 (2018) [PubMed]  Article
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50460726
Synonyms:
CHEMBL4225823
Type:
Small organic molecule
Emp. Form.:
C18H10F6N2OS
Mol. Mass.:
416.34
SMILES:
Nc1nc(c(s1)C(=O)c1ccccc1C(F)(F)F)-c1cccc(c1)C(F)(F)F
Structure:
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