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Target
Sterol O-acyltransferase 1
Ligand
BDBM50461448
Substrate
n/a
Meas. Tech.
ChEMBL_1771370 (CHEMBL4223482)
IC50
2100±n/a nM
Citation
 Kapojos, MM; Abdjul, DB; Yamazaki, H; Ohshiro, T; Rotinsulu, H; Wewengkang, DS; Sumilat, DA; Tomoda, H; Namikoshi, M; Uchida, R Callyspongiamides A and B, sterol O-acyltransferase inhibitors, from the Indonesian marine sponge Callyspongia sp. Bioorg Med Chem Lett 28:1911-1914 (2018) [PubMed]  Article
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | ACAT1 | Acyl-coenzyme A:cholesterol acyltransferase 1 | Cholesterol acyltransferase 1 | SOAT1 | SOAT1_CHLAE | Sterol O-acyltransferase 1
Type:
PROTEIN
Mol. Mass.:
64744.47
Organism:
Chlorocebus aethiops
Description:
ChEMBL_116975
Residue:
550
Sequence:
MVGEEKMSLRNRLSKSRENPEEDEDQRKPAKESLEAPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQRWATGYSKSSHPLINSLFHGFLFMVFQIGILGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMQFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVMMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
  
Inhibitor
Name:
BDBM50461448
Synonyms:
CHEMBL4227559
Type:
Small organic molecule
Emp. Form.:
C14H20Cl6N2O2
Mol. Mass.:
461.039
SMILES:
C[C@@H](C[C@@H]1N(C)C(=O)[C@H](C[C@H](C)C(Cl)(Cl)Cl)N(C)C1=O)C(Cl)(Cl)Cl |r|
Structure:
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