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Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50461449
Substrate
n/a
Meas. Tech.
ChEMBL_1771406 (CHEMBL4223518)
IC50
<10000±n/a nM
Citation
 Healy, MP; Allan, AC; Bailey, K; Billinton, A; Chessell, IP; Clayton, NM; Giblin, GMP; Kay, MA; Khaznadar, T; Michel, AD; Naylor, A; Price, H; Spalding, DJ; Stevens, DA; Swarbrick, ME; Wilson, AW Discovery of {4-[4,9-bis(ethyloxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetic acid (GSK726701A), a novel EP Bioorg Med Chem Lett 28:1892-1896 (2018) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_HUMAN | PGE receptor, EP1 subtype | PTGER1 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP1 subtype | Prostaglandin E2 receptor EP1 subtype (EP1) | Prostanoid EP1 receptor
Type:
Enzyme
Mol. Mass.:
41834.57
Organism:
Homo sapiens (Human)
Description:
P34995
Residue:
402
Sequence:
MSPCGPLNLSLAGEATTCAAPWVPNTSAVPPSGASPALPIFSMTLGAVSNLLALALLAQAAGRLRRRRSAATFLLFVASLLATDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTRPLLHAARVSVARARLALAAVAAVALAVALLPLARVGRYELQYPGTWCFIGLGPPGGWRQALLAGLFASLGLVALLAALVCNTLSGLALLRARWRRRSRRPPPASGPDSRRRWGAHGPRSASASSASSIASASTFFGGSRSSGSARRARAHDVEMVGQLVGIMVVSCICWSPMLVLVALAVGGWSSTSLQRPLFLAVRLASWNQILDPWVYILLRQAVLRQLLRLLPPRAGAKGGPAGLGLTPSAWEASSLRSSRHSGLSHF
  
Inhibitor
Name:
BDBM50461449
Synonyms:
CHEMBL4229058
Type:
Small organic molecule
Emp. Form.:
C24H22FNO5
Mol. Mass.:
423.4336
SMILES:
CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC(O)=O)c(F)c1
Structure:
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