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Target
RNA-directed RNA polymerase
Ligand
BDBM50239940
Substrate
n/a
Meas. Tech.
ChEMBL_1771863 (CHEMBL4223975)
EC50
64±n/a nM
Citation
 Liu, M; Xu, Q; Guo, S; Zuo, R; Hong, Y; Luo, Y; Li, Y; Gong, P; Liu, Y Design, synthesis, and structure-activity relationships of novel imidazo[4,5-c]pyridine derivatives as potent non-nucleoside inhibitors of hepatitis C virus NS5B. Bioorg Med Chem 26:2621-2631 (2018) [PubMed]  Article
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50239940
Synonyms:
CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sovaldi
Type:
Small organic molecule
Emp. Form.:
C22H29FN3O9P
Mol. Mass.:
529.4525
SMILES:
CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](C)(F)[C@@H]1O)Oc1ccccc1 |r|
Structure:
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