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Target
Dopamine beta-hydroxylase
Ligand
BDBM50024476
Substrate
n/a
Meas. Tech.
ChEMBL_59298 (CHEMBL884443)
IC50
27000±n/a nM
Citation
 Ross, ST; Kruse, LI; Ohlstein, EH; Erickson, RW; Ezekiel, M; Flaim, KE; Sawyer, JL; Berkowitz, BA Inhibitors of dopamine beta-hydroxylase. 3. Some 1-(pyridylmethyl)imidazole-2-thiones. J Med Chem 30:1309-13 (1987) [PubMed]
Target
Name:
Dopamine beta-hydroxylase
Synonyms:
DOPO_RAT | Dbh
Type:
PROTEIN
Mol. Mass.:
69869.10
Organism:
Rattus norvegicus
Description:
ChEMBL_59425
Residue:
620
Sequence:
MQPHLSHQPCWSLPSPSVREAASMYGTAVAIFLVILVAALQGSEPPESPFPYHIPLDPEGTLELSWNVSYDQEIIHFQLQVQGPRAGVLFGMSDRGEMENADLVMLWTDGDRTYFADAWSDQKGQIHLDTHQDYQLLQAQRVSNSLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQQVQLLKPEVSTPAMPADVQTMDIRAPDVLIPSTETTYWCYITELPLHFPRHHIIMYEAIVTEGNEALVHHMEVFQCTNESEAFPMFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGVPLGSSGSSRFLRLEVHYHNPRNIQGRRDSSGIRLHYTASLRPNEAGIMELGLVYTPLMAIPPQETTFVLTGYCTDRCTQMALPKSGIRIFASQLHTHLTGRKVITVLARDGQQREVVNRDNHYSPHFQEIRMLKNAVTVHQGDVLITSCTYNTENRTMATVGGFGILEEMCVNYVHYYPKTELELCKSAVDDGFLQKYFHIVNRFGNEEVCTCPQASVPQQFASVPWNSFNRDMLKALYNYAPISVHCNKTSAVRFPGNWNLQPLPNITSAVEEPDPRCPIRQTRGPAGPFVVITHGGRH
  
Inhibitor
Name:
BDBM50024476
Synonyms:
1-(5-Hydroxy-pyridin-2-ylmethyl)-1,3-dihydro-imidazole-2-thione | CHEMBL25525
Type:
Small organic molecule
Emp. Form.:
C9H9N3OS
Mol. Mass.:
207.252
SMILES:
Oc1ccc(Cn2cc[nH]c2=S)nc1
Structure:
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