Reaction Details  Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM50464475
Substrate
n/a
Meas. Tech.
ChEMBL_1780729 (CHEMBL4252246)
IC50
712±n/a nM
Citation
 Faria, RX; Oliveira, FH; Salles, JP; Oliveira, AS; von Ranke, NL; Bello, ML; Rodrigues, CR; Castro, HC; Louvis, AR; Martins, DL; Ferreira, VF 1,4-Naphthoquinones potently inhibiting P2X7 receptor activity. Eur J Med Chem 143:1361-1372 (2018) [PubMed]  Article
Target
Name:
P2X purinoceptor 7
Synonyms:
P2RX7_MOUSE | P2rx7 | P2x7
Type:
PROTEIN
Mol. Mass.:
68405.16
Organism:
Mus musculus
Description:
ChEMBL_1473824
Residue:
595
Sequence:
MPACCSWNDVLQYETNKVTRIQSTNYGTVKWVLHMIVFSYISFALVSDKLYQRKEPVISSVHTKVKGIAEVTENVTEGGVTKLGHSIFDTADYTFPLQGNSFFVMTNYVKSEGQVQTLCPEYPRRGAQCSSDRRCKKGWMDPQSKGIQTGRCVPYDKTRKTCEVSAWCPTEEEKEAPRPALLRSAENFTVLIKNNIHFPGHNYTTRNILPTMNGSCTFHKTWDPQCSIFRLGDIFQEAGENFTEVAVQGGIMGIEIYWDCNLDSWSHHCRPRYSFRRLDDKNTDESFVPGYNFRYAKYYKENNVEKRTLIKAFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLATVCIDLLINTYSSAFCRSGVYPYCKCCEPCTVNEYYYRKKCESIMEPKPTLKYVSFVDEPHIRMVDQQLLGKSLQVVKGQEVPRPQMDFSDLSRLSLSLHDSPLTPGQSEEIQLLHEEVAPKSGDSPSWCQCGNCLPSRLPEQRRALEELCCRRKPGRCITTSKLFHKLVLSRDTLQLLLLYQDPLLVLGEEATNSRLRHRAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKTEGQYSGFKYPY
  
Inhibitor
Name:
BDBM50464475
Synonyms:
CHEMBL4291798
Type:
Small organic molecule
Emp. Form.:
C10H5BrO3
Mol. Mass.:
253.049
SMILES:
OC1=C(Br)C(=O)c2ccccc2C1=O |c:1|
Structure:
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