Reaction Details  Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM50464790
Substrate
n/a
Meas. Tech.
ChEMBL_1782645 (CHEMBL4254162)
IC50
0.750000±n/a nM
Citation
 Ling, Y; Guo, J; Yang, Q; Zhu, P; Miao, J; Gao, W; Peng, Y; Yang, J; Xu, K; Xiong, B; Liu, G; Tao, J; Luo, L; Zhu, Q; Zhang, Y Development of novel ?-carboline-based hydroxamate derivatives as HDAC inhibitors with antiproliferative and antimetastatic activities in human cancer cells. Eur J Med Chem 144:398-409 (2018) [PubMed]  Article
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50464790
Synonyms:
CHEMBL4288953
Type:
Small organic molecule
Emp. Form.:
C26H22N4O2
Mol. Mass.:
422.4785
SMILES:
Cc1ccc(cc1)-c1nc(NCc2ccc(cc2)C(=O)NO)cc2c3ccccc3[nH]c12
Structure:
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