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Target
Proteasome subunit beta type-2
Ligand
BDBM50464962
Substrate
n/a
Meas. Tech.
ChEMBL_1783554 (CHEMBL4255071)
IC50
13200±n/a nM
Citation
 Richy, N; Sarraf, D; Maréchal, X; Janmamode, N; Le Guével, R; Genin, E; Reboud-Ravaux, M; Vidal, J Structure-based design of human immuno- and constitutive proteasomes inhibitors. Eur J Med Chem 145:570-587 (2018) [PubMed]  Article
Target
Name:
Proteasome subunit beta type-2
Synonyms:
20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22837.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1294233
Residue:
201
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
  
Inhibitor
Name:
BDBM50464962
Synonyms:
CHEMBL4290574
Type:
Small organic molecule
Emp. Form.:
C36H36N4O7
Mol. Mass.:
636.6936
SMILES:
CC(O)[C@@H](NC(=O)c1ccc(OCc2ccccc2)cc1)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1 |r|
Structure:
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