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Target
Beta-secretase 1
Ligand
BDBM22985
Substrate
n/a
Meas. Tech.
ChEMBL_1788653 (CHEMBL4260387)
IC50
7000±n/a nM
Citation
 Gay, M; Evrard, C; Descamps, F; Carato, P; Renault, N; Coevoet, M; Eddarkaoui, S; Baud, C; Larchanché, PE; Buée, L; El Bakali, J; Vingtdeux, V; Sergeant, N; Melnyk, P A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect ?-secretase inhibitors. Eur J Med Chem 159:104-125 (2018) [PubMed]  Article
Target
Name:
Beta-secretase 1
Synonyms:
ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-secretase (BACE) | Beta-secretase 1 | Beta-secretase 1 (BACE 1) | Beta-secretase 1 (BACE-1) | Beta-secretase 1 (BACE1) | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1) | beta-Secretase (BACE1)
Type:
Protein
Mol. Mass.:
55755.10
Organism:
Homo sapiens (Human)
Description:
P56817
Residue:
501
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRQQHDDFADDISLLK
  
Inhibitor
Name:
BDBM22985
Synonyms:
Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chlorochin | Chloroquine | Chloroquine, 17 | med.21724, Compound 8 | {4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine
Type:
Antimalarial
Emp. Form.:
C18H26ClN3
Mol. Mass.:
319.872
SMILES:
CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
Structure:
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