Reaction Details  Report a problem with these data
Target
Dihydroorotate dehydrogenase (fumarate)
Ligand
BDBM50466111
Substrate
n/a
Meas. Tech.
ChEMBL_1791599 (CHEMBL4263518)
IC50
361400±n/a nM
Citation
 Chibli, LA; Schmidt, TJ; Nonato, MC; Calil, FA; Da Costa, FB Natural products as inhibitors of Leishmania major dihydroorotate dehydrogenase. Eur J Med Chem 157:852-866 (2018) [PubMed]  Article
Target
Name:
Dihydroorotate dehydrogenase (fumarate)
Synonyms:
1.3.98.1 | DHODH | Dihydroorotate dehydrogenase (fumarate) | Dihydroorotate oxidase
Type:
PROTEIN
Mol. Mass.:
34659.43
Organism:
Leishmania major
Description:
ChEMBL_118088
Residue:
320
Sequence:
MSLQVNLLNNTFANPFMNAAGVMCTTTEELVAMTESASGSLVSKSCTPALREGNPTPRYQALPLGSINSMGLPNNGFDFYLAYAAEQHDYGKKPLFLSMSGLSMRENVEMCKRLAAVATEKGVILELNLSCPNVPGKPQVAYDFDAMRQCLTAVSEVYPHSFGVKMPPYFDFAHFDAAAEILNEFPKVQFITCINSIGNGLVIDAETESVVIKPKQGFGGLGGRYVLPTALANINAFYRRCPGKLIFGCGGVYTGEDAFLHVLAGASMVQVGTALQEEGPSIFERLTSELLGVMAKKRYQTLDEFRGKVRTLDGTAESTR
  
Inhibitor
Name:
BDBM50466111
Synonyms:
CHEBI:3768 | CHEMBL462825
Type:
Small organic molecule
Emp. Form.:
C20H26O7
Mol. Mass.:
378.4162
SMILES:
[H][C@]12OC(=O)C(=C)[C@]1([H])[C@H](CC(C)=CCC\C(CO)=C\2)OC(=O)C(=C)[C@@H](O)CO |r,t:19|
Structure:
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