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Target
Heparanase
Ligand
BDBM50466634
Substrate
n/a
Meas. Tech.
ChEMBL_1793531 (CHEMBL4265450)
IC50
370±n/a nM
Citation
 Messore, A; Madia, VN; Pescatori, L; Saccoliti, F; Tudino, V; De Leo, A; Bortolami, M; De Vita, D; Scipione, L; Pepi, F; Costi, R; Rivara, S; Scalvini, L; Mor, M; Ferrara, FF; Pavoni, E; Roscilli, G; Cassinelli, G; Milazzo, FM; Battistuzzi, G; Di Santo, R; Giannini, G Novel Symmetrical Benzazolyl Derivatives Endowed with Potent Anti-Heparanase Activity. J Med Chem 61:10834-10859 (2018) [PubMed]  Article
Target
Name:
Heparanase
Synonyms:
Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1
Type:
PROTEIN
Mol. Mass.:
61167.67
Organism:
Homo sapiens (Human)
Description:
ChEMBL_327900
Residue:
543
Sequence:
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVTIDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQSQVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCSGLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGSQLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYLNGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFAAGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLMASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLLRPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVAACI
  
Inhibitor
Name:
BDBM50466634
Synonyms:
CHEMBL4290499
Type:
Small organic molecule
Emp. Form.:
C37H30F2N6O9
Mol. Mass.:
740.6657
SMILES:
CC(NC(=O)Cc1ccc2oc(nc2c1)-c1ccc(NC(=O)Nc2ccc(cc2F)-c2nc3cc(CC(=O)NC(C)C(O)=O)ccc3o2)c(F)c1)C(O)=O
Structure:
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