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Target
Aurora kinase A
Ligand
BDBM50467014
Substrate
n/a
Meas. Tech.
ChEMBL_1794714 (CHEMBL4266831)
IC50
5.0±n/a nM
Citation
 Gyulavári, P; Szokol, B; Szabadkai, I; Brauswetter, D; Bánhegyi, P; Varga, A; Markó, P; Boros, S; Illyés, E; Szántai-Kis, C; Krekó, M; Czudor, Z; ?rfi, L Discovery and optimization of novel benzothiophene-3-carboxamides as highly potent inhibitors of Aurora kinases A and B. Bioorg Med Chem Lett 28:3265-3270 (2018) [PubMed]  Article
Target
Name:
Aurora kinase A
Synonyms:
AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45830.98
Organism:
Homo sapiens (Human)
Description:
O14965
Residue:
403
Sequence:
MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQAQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
  
Inhibitor
Name:
BDBM50467014
Synonyms:
CHEMBL4279747
Type:
Small organic molecule
Emp. Form.:
C18H22N6O4S2
Mol. Mass.:
450.535
SMILES:
CNC(=O)Nc1sc2c(cc(NS(=O)(=O)c3ccn(C)n3)cc2c1C(N)=O)C(C)C
Structure:
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