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Target
Aurora kinase B
Ligand
BDBM50467020
Substrate
n/a
Meas. Tech.
ChEMBL_1794715 (CHEMBL4266832)
IC50
29±n/a nM
Citation
 Gyulavári, P; Szokol, B; Szabadkai, I; Brauswetter, D; Bánhegyi, P; Varga, A; Markó, P; Boros, S; Illyés, E; Szántai-Kis, C; Krekó, M; Czudor, Z; ?rfi, L Discovery and optimization of novel benzothiophene-3-carboxamides as highly potent inhibitors of Aurora kinases A and B. Bioorg Med Chem Lett 28:3265-3270 (2018) [PubMed]  Article
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50467020
Synonyms:
CHEMBL4288081
Type:
Small organic molecule
Emp. Form.:
C18H20N4O4S3
Mol. Mass.:
452.571
SMILES:
CNC(=O)Nc1sc2c(cc(NS(=O)(=O)c3cccs3)cc2c1C(N)=O)C(C)C
Structure:
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