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Target
cGMP-dependent protein kinase
Ligand
BDBM50467124
Substrate
n/a
Meas. Tech.
ChEMBL_1794924 (CHEMBL4267041)
IC50
6.0±n/a nM
Citation
 Tsagris, DJ; Birchall, K; Bouloc, N; Large, JM; Merritt, A; Smiljanic-Hurley, E; Wheldon, M; Ansell, KH; Kettleborough, C; Whalley, D; Stewart, LB; Bowyer, PW; Baker, DA; Osborne, SA Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG). Bioorg Med Chem Lett 28:3168-3173 (2018) [PubMed]  Article
Target
Name:
cGMP-dependent protein kinase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
97679.99
Organism:
Plasmodium falciparum
Description:
ChEMBL_862297
Residue:
853
Sequence:
MEEDDNLKKGNERNKKKAIFSNDDFTGEDSLMEDHLELREKLSEDIDMIKTSLKNNLVCSTLNDNEILTLSNYMQFFVFKSGNLVIKQGEKGSYFFIINSGKFDVYVNDKKVKTMGKGSSFGEAALIHNTQRSATIIAETDGTLWGVQRSTFRATLKQLSNRNFNENRTFIDSVSVFDMLTEAQKNMITNACVIQNFKSGETIVKQGDYGDVLYILKEGKATVYINDEEIRVLEKGSYFGERALLYDEPRSATIIAKEPTACASICRKLLNIVLGNLQVVLFRNIMTEALQQSEIFKQFSGDQLNDLADTAIVRDYPANYNILHKDKVKSVKYIIVLEGKVELFLDDTSIGILSRGMSFGDQYVLNQKQPFKHTIKSLEVCKIALITETCLADCLGNNNIDASIDYNNKKSIIKKMYIFRYLTDKQCNLLIEAFRTTRYEEGDYIIQEGEVGSRFYIIKNGEVEIVKNKKRLRTLGKNDYFGERALLYDEPRTASVISKVNNVECWFVDKSVFLQIIQGPMLAHLEERIKMQDTKVEMDELETERIIGRGTFGTVKLVHHKPTKIRYALKCVSKRSIINLNQQNNIKLEREITAENDHPFIIRLVRTFKDSKYFYFLTELVTGGELYDAIRKLGLLSKSQAQFYLGSIILAIEYLHERNIVYRDLKPENILLDKQGYVKLIDFGCAKKVQGRAYTLVGTPHYMAPEVILGKGYGCTVDIWALGICLYEFICGPLPFGNDEEDQLEIFRDILTGQLTFPDYVTDTDSINLMKRLLCRLPQGRIGCSINGFKDIKDHPFFSNFNWDKLAGRLLDPPLVSKSETYAEDIDIKQIEEEDAEDDEEPLNDEDNWDIDF
  
Inhibitor
Name:
BDBM50467124
Synonyms:
CHEMBL4283774
Type:
Small organic molecule
Emp. Form.:
C18H17FN4S
Mol. Mass.:
340.418
SMILES:
CN1CCC(C1)c1nc(c(s1)-c1ccncn1)-c1ccc(F)cc1
Structure:
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