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Target
Acyl-CoA desaturase 1
Ligand
BDBM50467593
Substrate
n/a
Meas. Tech.
ChEMBL_1796484 (CHEMBL4268601)
IC50
3.8±n/a nM
Citation
 Iida, T; Ubukata, M; Mitani, I; Nakagawa, Y; Maeda, K; Imai, H; Ogoshi, Y; Hotta, T; Sakata, S; Sano, R; Morinaga, H; Negoro, T; Oshida, S; Tanaka, M; Inaba, T Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity. Eur J Med Chem 158:832-852 (2018) [PubMed]  Article
Target
Name:
Acyl-CoA desaturase 1
Synonyms:
ACOD1_MOUSE | Scd1
Type:
PROTEIN
Mol. Mass.:
41064.54
Organism:
Mus musculus
Description:
ChEMBL_1462109
Residue:
355
Sequence:
MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEGPPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTFPFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
  
Inhibitor
Name:
BDBM50467593
Synonyms:
CHEMBL4284259
Type:
Small organic molecule
Emp. Form.:
C19H19N3OS
Mol. Mass.:
337.439
SMILES:
Cc1csc(NC(=O)c2ccc(CNc3ccccc3C)cc2)n1
Structure:
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