Reaction Details  Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50103514
Substrate
n/a
Meas. Tech.
ChEMBL_1797474 (CHEMBL4269591)
Ki
3.0±n/a nM
Citation
 Angeli, A; Ferraroni, M; Supuran, CT Famotidine, an Antiulcer Agent, Strongly Inhibits  ACS Med Chem Lett 9:1035-1038 (2018) [PubMed]  Article
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50103514
Synonyms:
CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid | Pepcid Ac | Pepcid Rpd
Type:
Small organic molecule
Emp. Form.:
C8H15N7O2S3
Mol. Mass.:
337.445
SMILES:
NC(=N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
Structure:
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