Reaction Details  Report a problem with these data
Target
Carbonic anhydrase 5A, mitochondrial
Ligand
BDBM50103514
Substrate
n/a
Meas. Tech.
ChEMBL_1797471 (CHEMBL4269588)
Ki
1430±n/a nM
Citation
 Angeli, A; Ferraroni, M; Supuran, CT Famotidine, an Antiulcer Agent, Strongly Inhibits  ACS Med Chem Lett 9:1035-1038 (2018) [PubMed]  Article
Target
Name:
Carbonic anhydrase 5A, mitochondrial
Synonyms:
CA-VA | CA5 | CA5A | CAH5A_HUMAN | Carbonate dehydratase VA | Carbonic Anhydrase VA | Carbonic anhydrase 5A (CA VA) | Carbonic anhydrase 5A, mitochondrial | Carbonic anhydrase 5A, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VA (CA VA)
Type:
Enzyme
Mol. Mass.:
34755.54
Organism:
Homo sapiens (Human)
Description:
Human (cloned) isozyme
Residue:
305
Sequence:
MLGRNTWKTSAFSFLVEQMWAPLWSRSMRPGRWCSQRSCAWQTSNNTLHPLWTVPVSVPGGTRQSPINIQWRDSVYDPQLKPLRVSYEAASCLYIWNTGYLFQVEFDDATEASGISGGPLENHYRLKQFHFHWGAVNEGGSEHTVDGHAYPAELHLVHWNSVKYQNYKEAVVGENGLAVIGVFLKLGAHHQTLQRLVDILPEIKHKDARAAMRPFDPSTLLPTCWDYWTYAGSLTTPPLTESVTWIIQKEPVEVAPSQLSAFRTLLFSALGEEEKMMVNNYRPLQPLMNRKVWASFQATNEGTRS
  
Inhibitor
Name:
BDBM50103514
Synonyms:
CHEBI:4975 | Famotidine | Fluxid | MK-208 | Pepcid | Pepcid Ac | Pepcid Rpd
Type:
Small organic molecule
Emp. Form.:
C8H15N7O2S3
Mol. Mass.:
337.445
SMILES:
NC(=N)Nc1nc(CSCCC(=N)NS(N)(=O)=O)cs1
Structure:
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