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Target
Histamine H4 receptor
Ligand
BDBM50021529
Substrate
n/a
Meas. Tech.
ChEMBL_1799139 (CHEMBL4271431)
Ki
520±n/a nM
Citation
 Cascioferro, S; Parrino, B; Spanò, V; Carbone, A; Montalbano, A; Barraja, P; Diana, P; Cirrincione, G 1,3,5-Triazines: A promising scaffold for anticancer drugs development. Eur J Med Chem 142:523-549 (2017) [PubMed]  Article
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50021529
Synonyms:
CHEMBL3290578
Type:
Small organic molecule
Emp. Form.:
C14H17BrN6
Mol. Mass.:
349.229
SMILES:
CN1CCN(CC1)c1nc(N)nc(n1)-c1ccc(Br)cc1
Structure:
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