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Target
Serine/threonine-protein kinase B-raf
Ligand
BDBM50468570
Substrate
n/a
Meas. Tech.
ChEMBL_1799947 (CHEMBL4272239)
IC50
50±n/a nM
Citation
 Li, HL; Su, MM; Xu, YJ; Xu, C; Yang, YS; Zhu, HL Design and biological evaluation of novel triaryl pyrazoline derivatives with dioxane moiety for selective BRAF Eur J Med Chem 155:725-735 (2018) [PubMed]  Article
Target
Name:
Serine/threonine-protein kinase B-raf
Synonyms:
B-raf | BRAF_MOUSE | Braf | Proto-oncogene B-Raf | Serine/threonine-protein kinase B-raf
Type:
PROTEIN
Mol. Mass.:
88789.83
Organism:
Mus musculus
Description:
ChEMBL_105657
Residue:
804
Sequence:
MAALSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLVFQTPTDASRNNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPVPQEEASFPETALPSGSSSAPPSDSTGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDEKFPEVELQDQRDLIRDQGFRGDGAPLNQLMRCLRKYQSRTPSPLLHSVPSEIVFDFEPGPVFRGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSSSEDRSRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGEFAAFK
  
Inhibitor
Name:
BDBM50468570
Synonyms:
CHEMBL4290513
Type:
Small organic molecule
Emp. Form.:
C24H20BrN3O2S
Mol. Mass.:
494.404
SMILES:
Brc1ccc(cc1)C1=NN(C(C1)c1ccc2OCCOc2c1)C(=S)Nc1ccccc1 |t:8|
Structure:
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