Reaction Details  Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM50241179
Substrate
n/a
Meas. Tech.
ChEMBL_1800812 (CHEMBL4273104)
IC50
20210±n/a nM
Citation
 Channar, PA; Afzal, S; Ejaz, SA; Saeed, A; Larik, FA; Mahesar, PA; Lecka, J; Sévigny, J; Erben, MF; Iqbal, J Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile. Eur J Med Chem 156:461-478 (2018) [PubMed]  Article
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM50241179
Synonyms:
(S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole | 6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole | 6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole (Levamisole) | 6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole(Levamisole) | 6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole(tetramisole) | CHEMBL1454 | LEVAMISOLE | LEVAMISOLE HYDROCHLORIDE | TCMDC-125847 | cid_68628 | levamisole;6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole | tetramisole;6-Phenyl-2,3,5,6-tetrahydro-imidazo[2,1-b]thiazole
Type:
Small organic molecule
Emp. Form.:
C11H12N2S
Mol. Mass.:
204.291
SMILES:
C1CN2C[C@@H](N=C2S1)c1ccccc1 |r,c:5|
Structure:
Search PDB for entries with ligand similarity: