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Target
Tyrosine-protein kinase receptor TYRO3
Ligand
BDBM50469372
Substrate
n/a
Meas. Tech.
ChEMBL_1804042 (CHEMBL4276334)
IC50
4.3±n/a nM
Citation
 Zhao, J; Zhang, D; Zhang, W; Stashko, MA; DeRyckere, D; Vasileiadi, E; Parker, RE; Hunter, D; Liu, Q; Zhang, Y; Norris-Drouin, J; Li, B; Drewry, DH; Kireev, D; Graham, DK; Earp, HS; Frye, SV; Wang, X Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group. J Med Chem 61:10242-10254 (2018) [PubMed]  Article
Target
Name:
Tyrosine-protein kinase receptor TYRO3
Synonyms:
BYK | DTK | RSE | SKY | TIF | TYRO3 | TYRO3_HUMAN | Tyrosine-protein kinase SKY
Type:
Protein
Mol. Mass.:
96894.13
Organism:
Homo sapiens (Human)
Description:
Q06418
Residue:
890
Sequence:
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
  
Inhibitor
Name:
BDBM50469372
Synonyms:
CHEMBL4280761
Type:
Small organic molecule
Emp. Form.:
C30H44N6O
Mol. Mass.:
504.71
SMILES:
CCCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)-c1ccc(CN2CCN(C)CC2)cc1 |r,wU:14.13,wD:17.17,4.4,(29.82,-8.23,;31.15,-9,;32.48,-8.23,;33.82,-9,;35.15,-8.23,;35.15,-6.69,;36.48,-9,;37.82,-8.23,;37.82,-6.69,;39.15,-5.92,;40.48,-6.68,;41.96,-6.2,;42.87,-7.46,;41.96,-8.71,;42.71,-10.05,;44.24,-10.08,;44.99,-11.43,;44.19,-12.75,;44.93,-14.1,;42.65,-12.72,;41.91,-11.37,;40.48,-8.23,;39.15,-9,;42.67,-4.84,;44.21,-4.78,;44.93,-3.42,;44.1,-2.11,;44.81,-.75,;46.35,-.68,;47.17,-1.99,;48.71,-1.93,;49.42,-.56,;50.96,-.5,;48.6,.75,;47.06,.69,;42.55,-2.18,;41.85,-3.55,)|
Structure:
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