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Target
Adenosine receptor A2b
Ligand
BDBM50470486
Substrate
n/a
Meas. Tech.
ChEMBL_1802980 (CHEMBL4275272)
Ki
>3000±n/a nM
Citation
 Federico, S; Margiotta, E; Salmaso, V; Pastorin, G; Kachler, S; Klotz, KN; Moro, S; Spalluto, G [1,2,4]Triazolo[1,5-c]pyrimidines as adenosine receptor antagonists: Modifications at the 8 position to reach selectivity towards A Eur J Med Chem 157:837-851 (2018) [PubMed]  Article
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50470486
Synonyms:
CHEMBL4285563
Type:
Small organic molecule
Emp. Form.:
C18H15N5O3
Mol. Mass.:
349.3434
SMILES:
CNc1ncc(C(=O)OCc2ccccc2)c2nc(nn12)-c1ccco1
Structure:
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