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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50472190
Substrate
n/a
Meas. Tech.
ChEMBL_155726 (CHEMBL760760)
IC50
5.0±n/a nM
Citation
 Christensen, SB; Guider, A; Forster, CJ; Gleason, JG; Bender, PE; Karpinski, JM; DeWolf, WE; Barnette, MS; Underwood, DC; Griswold, DE; Cieslinski, LB; Burman, M; Bochnowicz, S; Osborn, RR; Manning, CD; Grous, M; Hillegas, LM; Bartus, JO; Ryan, MD; Eggleston, DS; Haltiwanger, RC; Torphy, TJ 1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma. J Med Chem 41:821-35 (1998) [PubMed]  Article
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50472190
Synonyms:
CHEMBL167638
Type:
Small organic molecule
Emp. Form.:
C18H24O4
Mol. Mass.:
304.3808
SMILES:
COc1ccc(cc1OC1CCCC1)C1CCC(C1)C(O)=O
Structure:
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