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Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50472866
Substrate
n/a
Meas. Tech.
ChEMBL_48108 (CHEMBL663095)
Ki
1.1±n/a nM
Citation
 Ursini, A; Capelli, AM; Carr, RA; Cassarà, P; Corsi, M; Curcuruto, O; Curotto, G; Dal Cin, M; Davalli, S; Donati, D; Feriani, A; Finch, H; Finizia, G; Gaviraghi, G; Marien, M; Pentassuglia, G; Polinelli, S; Ratti, E; Reggiani, AM; Tarzia, G; Tedesco, G; Tranquillini, ME; Trist, DG; Van Amsterdam, FT; Reggiani, A Synthesis and SAR of new 5-phenyl-3-ureido-1,5-benzodiazepines as cholecystokinin-B receptor antagonists. J Med Chem 43:3596-613 (2000) [PubMed]  Article
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48445.79
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:
447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50472866
Synonyms:
CHEMBL120021
Type:
Small organic molecule
Emp. Form.:
C35H39N5O3
Mol. Mass.:
577.7159
SMILES:
[H][C@]12C[C@]3([H])C[C@]([H])(C1)CC(CN1c4ccccc4N(c4ccccc4)C(=O)C(NC(=O)Nc4cccc(c4)N(C)C)C1=O)(C2)C3 |TLB:8:1:45:6.9.5,8:6:45:1.44.2,THB:2:3:9:1.44.8,2:1:9:3.45.5|
Structure:
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