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Target
Small conductance calcium-activated potassium channel protein 1/2/3
Ligand
BDBM50084846
Substrate
n/a
Meas. Tech.
ChEMBL_177948 (CHEMBL785164)
IC50
310±n/a nM
Citation
 Campos Rosa, J; Galanakis, D; Piergentili, A; Bhandari, K; Ganellin, CR; Dunn, PM; Jenkinson, DH Synthesis, molecular modeling, and pharmacological testing of bis-quinolinium cyclophanes: potent, non-peptidic blockers of the apamin-sensitive Ca(2+)-activated K(+) channel. J Med Chem 43:420-31 (2000) [PubMed]  Article
Target
Name:
Small conductance calcium-activated potassium channel protein 1/2/3
Synonyms:
Small conductance calcium-activated potassium channel
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1559987
Components:
This complex has 3 components.
Component 1
Name:
Small conductance calcium-activated potassium channel protein 3
Synonyms:
KCNN3_RAT | Kcnn3 | SK3 | Small conductance calcium-activated potassium channel
Type:
PROTEIN
Mol. Mass.:
81476.29
Organism:
Rattus norvegicus
Description:
ChEMBL_494975
Residue:
732
Sequence:
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQLQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC
  
Component 2
Name:
Small conductance calcium-activated potassium channel protein 1
Synonyms:
KCNN1_RAT | Kcnn1 | Potassium Channel, Ca2+ Act., VS | Sk1 | Small conductance calcium-activated potassium channel
Type:
Enzyme Catalytic Domain
Mol. Mass.:
59231.59
Organism:
RAT
Description:
Potassium Channel, Ca2+ Act., VS 0 RAT::P70606
Residue:
536
Sequence:
MSSRSHNGSVGRPLGSGPGFLGWEPVDPEAGRPRQPTQGPGLQMMAKGQPAGLSPSGPRGHSQAQEEEEEEEDEDRPGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWERVSLISLELAVCAIHPVPGHYRFTWTARLAFSLVPSAAEADVDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSISSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQSRVRKHQRKFLQAIHQAQKLRTVKIEQGKVNDQANTLADLAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPSLIAQAICPLPPPWPGPSHLTTAAQSPQSHWLPTTASDCG
  
Component 3
Name:
Small conductance calcium-activated potassium channel protein 2
Synonyms:
KCNN2_RAT | Kcnn2 | Small conductance calcium-activated potassium channel | Small conductance calcium-activated potassium channel protein 2 | Small conductance calcium-activated potassium channel protein 2 (KCa2.2)
Type:
Protein
Mol. Mass.:
63876.72
Organism:
Rattus norvegicus (Rat)
Description:
P70604
Residue:
580
Sequence:
MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
  
Inhibitor
Name:
BDBM50084846
Synonyms:
1-[7-(4-amino-1-quinoliniumylmethyl)-9H-2-fluorenylmethyl]-4-quinoliniumamine | CHEMBL6356
Type:
Small organic molecule
Emp. Form.:
C33H28N4
Mol. Mass.:
480.6011
SMILES:
[NH2+]=c1ccn(Cc2ccc-3c(Cc4cc(Cn5ccc(=[NH2+])c6ccccc56)ccc-34)c2)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: