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Target
Urotensin-2 receptor
Ligand
BDBM50164424
Substrate
n/a
Meas. Tech.
ChEMBL_210780 (CHEMBL816597)
EC50
200±n/a nM
Citation
 Croston, GE; Olsson, R; Currier, EA; Burstein, ES; Weiner, D; Nash, N; Severance, D; Allenmark, SG; Thunberg, L; Ma, JN; Mohell, N; O'Dowd, B; Brann, MR; Hacksell, U Discovery of the first nonpeptide agonist of the GPR14/urotensin-II receptor: 3-(4-chlorophenyl)-3-(2- (dimethylamino)ethyl)isochroman-1-one (AC-7954). J Med Chem 45:4950-3 (2002) [PubMed]  Article
Target
Name:
Urotensin-2 receptor
Synonyms:
G-protein coupled receptor 14 | G-protein coupled sensory epithelial neuropeptide-like receptor | Gpr14 | Senr | UR-II-R | UR2R_RAT | Urotensin-II | Uts2r
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42725.34
Organism:
RAT
Description:
Urotensin-II UTS2R RAT::P49684
Residue:
386
Sequence:
MALSLESTTSFHMLTVSGSTVTELPGDSNVSLNSSWSGPTDPSSLKDLVATGVIGAVLSAMGVVGMVGNVYTLVVMCRFLRASASMYVYVVNLALADLLYLLSIPFIIATYVTKDWHFGDVGCRVLFSLDFLTMHASIFTLTIMSSERYAAVLRPLDTVQRSKGYRKLLVLGTWLLALLLTLPMMLAIQLVRRGSKSLCLPAWGPRAHRTYLTLLFGTSIVGPGLVIGLLYVRLARAYWLSQQASFKQTRRLPNPRVLYLILGIVLLFWACFLPFWLWQLLAQYHEAMPLTPETARIVNYLTTCLTYGNSCINPFLYTLLTKNYREYLRGRQRSLGSSCHSPGSPGSFLPSRVHLQQDSGRSLSSSSQQATETLMLSPVPRNGALL
  
Inhibitor
Name:
BDBM50164424
Synonyms:
3-(4-Chloro-phenyl)-3-(2-dimethylamino-ethyl)-isochroman-1-one | 3-(4-chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one | CHEMBL192359
Type:
Small organic molecule
Emp. Form.:
C19H20ClNO2
Mol. Mass.:
329.821
SMILES:
CN(C)CCC1(Cc2ccccc2C(=O)O1)c1ccc(Cl)cc1
Structure:
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