Reaction Details  Report a problem with these data
Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50476101
Substrate
n/a
Meas. Tech.
ChEMBL_425416 (CHEMBL908498)
Ki
12±n/a nM
Citation
 Chimenti, F; Maccioni, E; Secci, D; Bolasco, A; Chimenti, P; Granese, A; Befani, O; Turini, P; Alcaro, S; Ortuso, F; Cardia, MC; Distinto, S Selective inhibitory activity against MAO and molecular modeling studies of 2-thiazolylhydrazone derivatives. J Med Chem 50:707-12 (2007) [PubMed]  Article
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_BOVIN | Amine oxidase [flavin-containing] A | MAO-A | MAOA | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A | Monoamine oxidase type A
Type:
PROTEIN
Mol. Mass.:
59764.63
Organism:
Bos taurus
Description:
ChEMBL_1501477
Residue:
527
Sequence:
MESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHVDYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKLRSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADRLAKVHKDIRKRKICELYAKVLGSQEALHPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAEDVPAVEITPSFWERNLPSVSGLLKIVGFSTSITALWFVMYRFRLLSRS
  
Inhibitor
Name:
BDBM50476101
Synonyms:
CHEMBL221392
Type:
Small organic molecule
Emp. Form.:
C11H9Cl2N3S
Mol. Mass.:
286.18
SMILES:
Cc1csc(N\N=C\c2ccc(Cl)cc2Cl)n1
Structure:
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