Reaction Details  Report a problem with these data
Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50326652
Substrate
n/a
Meas. Tech.
ChEMBL_425417 (CHEMBL908499)
Ki
91±n/a nM
Citation
 Chimenti, F; Maccioni, E; Secci, D; Bolasco, A; Chimenti, P; Granese, A; Befani, O; Turini, P; Alcaro, S; Ortuso, F; Cardia, MC; Distinto, S Selective inhibitory activity against MAO and molecular modeling studies of 2-thiazolylhydrazone derivatives. J Med Chem 50:707-12 (2007) [PubMed]  Article
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_BOVIN | Amine oxidase [flavin-containing] B | MAO-B | MAOB | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B | Monoamine oxidase type B
Type:
PROTEIN
Mol. Mass.:
58428.94
Organism:
Bos taurus
Description:
ChEMBL_1501478
Residue:
520
Sequence:
MSSKCDVVVVGGGISGMAAAKLLHDSGLNVIVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNHILRLSKELGLETYKVNEVERLIHHTKGKSYPFRGSFPSVWNPITYLDHNNLWRTMDDMGREIPSDAPWKAPLAEQWDLMTMKELLDKICWTESSKQLAILFVNLCVTAEIHEVSALWFLWYVKQCGGTTRIFSTSNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIHIDQTGENVLVETLNHELYEAKYVISAVPPVLGMKIHFNPPLPMMRNQLITRVPLGSVIKSIVYYKEPFWRNMDYCGSMIIEGEEAPVAYALDDTKPDGSYPAIIGFILAHKARKLARLTKEERLKKLCDLYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTSYFPPGIMTQYGRVLRQPVGRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWLPEPESVDVPAKPITTTFLQRHLPSVPGLLKLIGLTTIFSATALGFLAHKRGLLVRI
  
Inhibitor
Name:
BDBM50326652
Synonyms:
1-cyclohexylidene-2-(4-phenylthiazol-2-yl)hydrazine | 2-(2-cyclohexylidenehydrazinyl)-4-phenylthiazole | CHEMBL220495
Type:
Small organic molecule
Emp. Form.:
C15H17N3S
Mol. Mass.:
271.381
SMILES:
[#6]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#7]\[#7]-c1nc(cs1)-c1ccccc1
Structure:
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