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Target
Presenilin-1
Ligand
BDBM50476438
Substrate
n/a
Meas. Tech.
ChEMBL_440752 (CHEMBL889849)
IC50
11±n/a nM
Citation
 Pissarnitski, DA; Asberom, T; Bara, TA; Buevich, AV; Clader, JW; Greenlee, WJ; Guzik, HS; Josien, HB; Li, W; McEwan, M; McKittrick, BA; Nechuta, TL; Parker, EM; Sinning, L; Smith, EM; Song, L; Vaccaro, HA; Voigt, JH; Zhang, L; Zhang, Q; Zhao, Z 2,6-Disubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors. Bioorg Med Chem Lett 17:57-62 (2007) [PubMed]  Article
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50476438
Synonyms:
CHEMBL233298
Type:
Small organic molecule
Emp. Form.:
C29H37ClFN3O4S
Mol. Mass.:
578.138
SMILES:
[H][C@]1(CCC[C@H](COC(=O)N2CCC(CC2)N2CCCCC2)N1S(=O)(=O)c1ccc(Cl)cc1)c1cccc(F)c1 |r|
Structure:
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