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Target
Integrase
Ligand
BDBM50121880
Substrate
n/a
Meas. Tech.
ChEMBL_440973 (CHEMBL890063)
IC50
10.0±n/a nM
Citation
 Petrocchi, A; Koch, U; Matassa, VG; Pacini, B; Stillmock, KA; Summa, V From dihydroxypyrimidine carboxylic acids to carboxamide HIV-1 integrase inhibitors: SAR around the amide moiety. Bioorg Med Chem Lett 17:350-3 (2007) [PubMed]  Article
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50121880
Synonyms:
CHEMBL216874
Type:
Small organic molecule
Emp. Form.:
C16H12FN3O3S
Mol. Mass.:
345.348
SMILES:
Oc1nc(nc(C(=O)NCc2ccc(F)cc2)c1O)-c1cccs1
Structure:
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