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Target
Reverse transcriptase protein
Ligand
BDBM50477189
Substrate
n/a
Meas. Tech.
ChEMBL_450286 (CHEMBL900567)
Ki
470±n/a nM
Citation
 Mai, A; Artico, M; Rotili, D; Tarantino, D; Clotet-Codina, I; Armand-Ugón, M; Ragno, R; Simeoni, S; Sbardella, G; Nawrozkij, MB; Samuele, A; Maga, G; Esté, JA Synthesis and biological properties of novel 2-aminopyrimidin-4(3H)-ones highly potent against HIV-1 mutant strains. J Med Chem 50:5412-24 (2007) [PubMed]  Article
Target
Name:
Reverse transcriptase protein
Synonyms:
Reverse Transcriptase | Reverse Transcriptase (A62V) | Reverse Transcriptase (F61A)
Type:
Protein
Mol. Mass.:
30203.56
Organism:
Human immunodeficiency virus 1
Description:
Q9WJQ2
Residue:
259
Sequence:
PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPVFAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWTVQPIVLPEKDSWTVNDIQK
  
Inhibitor
Name:
BDBM50477189
Synonyms:
CHEMBL239281
Type:
Small organic molecule
Emp. Form.:
C16H19F2N3O
Mol. Mass.:
307.3384
SMILES:
CCCNc1nc(C(C)c2c(F)cccc2F)c(C)c(=O)[nH]1
Structure:
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