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Target
Integrase
Ligand
BDBM50142737
Substrate
n/a
Meas. Tech.
ChEMBL_458969 (CHEMBL925063)
IC50
7000±n/a nM
Citation
 Dubey, S; Satyanarayana, YD; Lavania, H Development of integrase inhibitors for treatment of AIDS: an overview. Eur J Med Chem 42:1159-68 (2007) [PubMed]  Article
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50142737
Synonyms:
(E)-6-(1-Benzyl-1H-pyrrol-2-yl)-2,4-dioxo-hex-5-enoic acid | (E)-6-(1-benzyl-1H-pyrrol-2-yl)-2,4-dioxohex-5-enoic acid | CHEMBL49201
Type:
Small organic molecule
Emp. Form.:
C17H15NO4
Mol. Mass.:
297.3053
SMILES:
OC(=O)C(=O)CC(=O)C=Cc1cccn1Cc1ccccc1 |w:8.7|
Structure:
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