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Target
Reverse transcriptase
Ligand
BDBM33410
Substrate
n/a
Meas. Tech.
ChEMBL_561277 (CHEMBL1016225)
IC50
40000±n/a nM
Citation
 Billamboz, M; Bailly, F; Barreca, ML; De Luca, L; Mouscadet, JF; Calmels, C; Andréola, ML; Witvrouw, M; Christ, F; Debyser, Z; Cotelle, P Design, synthesis, and biological evaluation of a series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as dual inhibitors of human immunodeficiency virus type 1 integrase and the reverse transcriptase RNase H domain. J Med Chem 51:7717-30 (2008) [PubMed]  Article
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM33410
Synonyms:
CHEMBL16755 | N-hydroxyisoquinolinedione, 2
Type:
Small organic molecule
Emp. Form.:
C9H7NO3
Mol. Mass.:
177.1568
SMILES:
ON1C(=O)Cc2ccccc2C1=O
Structure:
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