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Target
Integrase
Ligand
BDBM50479830
Substrate
n/a
Meas. Tech.
ChEMBL_542592 (CHEMBL1014188)
IC50
9000±n/a nM
Citation
 Sechi, M; Rizzi, G; Bacchi, A; Carcelli, M; Rogolino, D; Pala, N; Sanchez, TW; Taheri, L; Dayam, R; Neamati, N Design and synthesis of novel dihydroquinoline-3-carboxylic acids as HIV-1 integrase inhibitors. Bioorg Med Chem 17:2925-35 (2009) [PubMed]  Article
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50479830
Synonyms:
CHEMBL464213
Type:
Small organic molecule
Emp. Form.:
C21H21N3O6
Mol. Mass.:
411.4079
SMILES:
CCCCCn1c2ccccc2c(O)c(C(=O)Nc2cc(ccc2O)[N+]([O-])=O)c1=O
Structure:
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