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Target
Integrase
Ligand
BDBM50480457
Substrate
n/a
Meas. Tech.
ChEMBL_574490 (CHEMBL1030329)
IC50
6340±n/a nM
Citation
 Marchand, C; Beutler, JA; Wamiru, A; Budihas, S; Möllmann, U; Heinisch, L; Mellors, JW; Le Grice, SF; Pommier, Y Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H. Antimicrob Agents Chemother 52:361-4 (2008) [PubMed]  Article
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50480457
Synonyms:
CHEMBL557286
Type:
Small organic molecule
Emp. Form.:
C29H24N2O8
Mol. Mass.:
528.5095
SMILES:
CCCn1ncc2cc3CCc4c(OC)c5C(=O)c6c(O)c(C)c(O)cc6C(=O)c5c(O)c4-c3c(O)c2c1=O
Structure:
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