Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50480460
Substrate
n/a
Meas. Tech.
ChEMBL_574490 (CHEMBL1030329)
IC50
3450±n/a nM
Citation
Marchand, C; Beutler, JA; Wamiru, A; Budihas, S; Möllmann, U; Heinisch, L; Mellors, JW; Le Grice, SF; Pommier, Y Madurahydroxylactone derivatives as dual inhibitors of human immunodeficiency virus type 1 integrase and RNase H. Antimicrob Agents Chemother 52:361-4 (2008) [PubMed] Article
More Info.:
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED