Reaction Details  Report a problem with these data
Target
Reverse transcriptase
Ligand
BDBM50164648
Substrate
n/a
Meas. Tech.
ChEMBL_583929 (CHEMBL1061780)
Kd
2080±n/a nM
Citation
 Zelina, S; Sheen, CW; Radzio, J; Mellors, JW; Sluis-Cremer, N Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine. Antimicrob Agents Chemother 52:157-63 (2008) [PubMed]  Article
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50164648
Synonyms:
2'-deoxythymidine triphosphate | 5'-TTP | CHEMBL363559 | dTTP | dThd5'PPP | deoxy-TTP | pppdT | thymidine 5'-(tetrahydrogen triphosphate) | thymidine 5'-triphosphate
Type:
Small organic molecule
Emp. Form.:
C10H17N2O14P3
Mol. Mass.:
482.1683
SMILES:
Cc1cn([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)c(=O)[nH]c1=O |r|
Structure:
Search PDB for entries with ligand similarity: