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Target
Outer-membrane lipoprotein carrier protein
Ligand
BDBM50482422
Substrate
n/a
Meas. Tech.
ChEMBL_647954 (CHEMBL1218538)
Kd
7500±n/a nM
Citation
 Pathania, R; Zlitni, S; Barker, C; Das, R; Gerritsma, DA; Lebert, J; Awuah, E; Melacini, G; Capretta, FA; Brown, ED Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. Nat Chem Biol 5:849-56 (2009) [PubMed]  Article
Target
Name:
Outer-membrane lipoprotein carrier protein
Synonyms:
LOLA_ECOLI | Outer-membrane lipoprotein carrier protein | P20 | lolA | lplA | yzzV | yzzV
Type:
PROTEIN
Mol. Mass.:
22497.28
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_109162
Residue:
203
Sequence:
MKKIAITCALLSSLVASSVWADAASDLKSRLDKVSSFHASFTQKVTDGSGAAVQEGQGDLWVKRPNLFNWHMTQPDESILVSDGKTLWFYNPFVEQATATWLKDATGNTPFMLIARNQSSDWQQYNIKQNGDDFVLTPKASNGNLKQFTINVGRDGTIHQFSAVEQDDQRSSYQLKSQQNGAVDAAKFTFTPPQGVTVDDQRK
  
Inhibitor
Name:
BDBM50482422
Synonyms:
CHEMBL1213376
Type:
Small organic molecule
Emp. Form.:
C20H24ClN3O2S
Mol. Mass.:
405.941
SMILES:
COc1ccc(CCN2CNC(SCc3ccc(Cl)cc3)=NC2)cc1OC |c:21|
Structure:
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